Synthesizing, radiolabeling and investigation of radiopharmaceutical potential of magnetic poly(HEMA-APH) nanoparticles with iodine-131

Nanotechnology is a highly promising application platform to improve therapeutic effectiveness and safety profiles in the treatment of multiple types of cancer, as it is specific to site, limits multi-drug resistance and efficiently delivers anticancer agents. A wide variety of nanoparticle-based systems are available for cancer detection, diagnosis and treatment includingliposomes, polymeric micelles, nanosystems, nanoshells, fullerene-based derivatives, carbon nanotubes, dendrimers, quantum dots, gold nanoparticles, solid lipid nanoparticles, nanowires, paramagnetic nanoparticles, etc. The ability of nanoparticles in cancer treatment has dual significance. Firstly, nanoparticles play as drug carrier systems. Secondly, when they are exposed to appropriate wavelengths, nanoparticles heat up without heating the body. Thus, nanoparticles selectively kill cancerous cells.In light of all of the data given, the aim of current study is to synthesize magnetic poly(HEMA-APH) using non-surfactant emulsion polymerization between functional monomer anilinephtalein (APH) and side monomer poly(2-hydroxyethyl methacrylate) poly(HEMA) and to radiolabel the related polymer with 131I to investigate radiopharmaceutical potential of 131-mag-poly(HEMA-APH) on experimental animals.To achieve this, in the first stage APH molecule was synthesized and then polymerization reaction was done and magnetic poly(HEMA-APH) nanopolymer was obtained. In the next stage, mag-poly(HEMA-APH) polymer obtained was radiolabeled with 131I and quality-control studies of radiolabeled compound was done. In consequence of these studies, radiolabeling yield of 131I-mag-poly(HEMA-APH) was found to be about %90. In the final stage, scintigraphy and biodistribution studies on experimental animals were done. In the result of scintigraphy studies carried out on female and male albino wistar rats, it was observed that radiolabeled compound showed high uptake in the heart, the liver, the kidney and the stomach. In consequence of these studies, target organs for female and male Albino Wistar rats were determined to be uterus, ovarian and lungs, prostate respectively.In conclusion, mag-poly(HEMA-APH) molecule was successfully radiolabeled with 131I using iodogen method. Showing high uptake in the uterus, the ovarian, the lung and the prostate by 131I-mag-poly(HEMA-APH) reveals the potential of this radioiodinated compound to bu used in the diagnostics and therapy in diseases related with these organs. Using mag-poly(HEMA-APH) for this purpose will only be possible if the cell and the xenograft studies planned to be carry out in subsequent stages yields positive results.