The relationship between the soluble HLA-G levels in maternal serum and pregnancy outcomes

ABSTRACTIntroduction and Objective: Preeclampsia, intrauterine growth retardation, oligohydramnios, abortus, preterm birth and preterm rupture of membranes are significant pregnancy complications. İnsufficient trophoblastic invasion is play important role of the pregnancy complications?s pathophysiology that said above. Soluble HLA-G1/G5 is a molecule that associated with trophoblast invasion. The studies about prediction of pregnancy complications is made. When pregnancy complications predict early, essential strategies improved and prevention will be come in to question. Aim of our study was investigate relationship first and second soluble HLA-G1/G5 levels, PAPP-A, free beta hCG, AFP, second trimester uterin artery doppler parameters with pregnancy complications.Materials and Methods: In our prospective study 180 pregnant followed up.In our study in addition to the pregnants that applicant for 11-14 week down syndrome screening PAPP-A, free beta hCG, NT values, maternal blood soluble HLA-G1/G5 levels recorded. Pregnants AFP levels during 16-18 week and uterine artery doppler parameters during recorded. In our study the relationship stated parameters with pregnancy complications are investigated. In addition evaluation of predictive values of markers, we compared the markers relation.The pregnants classificated as normal pregnancy, preeclampsia, oligohydramios, IUGR, abortus, preterm birth, PROM 7 different groups.Results: First and second trimester HLA-G1/G5 levels was not significantly different between groups. But in preeclamptic patients first trimester HLA-G1/G5 levels and PAPP-A levels was significantly significantly lower than non-preeclamptic pregnants.Conclusions: If pregnancy complications predicted in early pregnancy, high risk pregnants follow up closely. In this wise pregnancy complications will ve diagnose early, necessary preventative methods will be possible. But large series that suppport of our study is needed.Key words: Soluble HLA-G, first trimester, pregnancy complications