Cognitive functions in adolescents with methamphetamine use disorder; evaluation of the relationship between TAFA5/FAM19A5, pro-inflammatory cytokines, S100B, BDNF and oxidative stress levels

Objective: Methamphetamine is a substance that is increasingly used and causes neurotoxicity. It has been reported in the literature that chronic methamphetamine use causes deterioration in cognitive functions. The aim of this study was to evaluate the relationship between cognitive impairment and inflammatory processes in adolescents with methamphetamine use disorder. Method: Cognitive tests of adolescents with methamphetamine use disorder without chronic inflammatory disease were evaluated with a computer-based program (CNS-VS). The biochemical parameters in the blood plasma of all participants participating in the study were examined. (IL-1beta, IL-6, TNF-a, BDNF, FAM19A5, TAS, TOS). Results: Cognitive impairment differed significantly between the groups. Cognitive impairment levels of adolescents using METH were negatively correlated with BDNF levels. Executive functions were associated with IL-6. Other biochemical parameters were not associated with cognitive impairment. A negative significant difference was found between the duration of methamphetamine use and cognitive impairment. Conclusions: In our study, it was determined that there is a relationship between cognitive impairment of adolescent with methamphetamine users and BDNF levels, IL-6 levels. The reason why other parameters could not be found related may be increase and decrease in the form of fluctuations inmarker levels. However, considering that the evaluation is cross-sectional, it is important to support the results with longitudinal studies.