Methyl parathion nephrotoxicity in rats and protective role of vitamins C and E

Methyl parathion, an organophosphorous insecticide, is widely used inagricultural control and causes poisoning. In the present study, methylparathion (0,28 mg/kg day), vitamin C (200 mg/kg day)+vitamin E (200 mg/kgday), vitamin C (200 mg/kg day)+vitamin E (200 mg/kg day)+ methyl parathion(0,28 mg/kg day) were given to male rats through gavage. Body and kidneyweights of the rats were weightened, histopathological changes wereinvestigated using light microscope and residue analyses were done with gaschromatography 24 hrs, 4 and 7 weeks after administration. No staticallysignificant changes of body and kidney weights were observed in methylparathion treated group and vitamin C+vitamin E+ methyl parathion treatedgroup 24 hrs after, statistically significant decrease were observed after 4 and 7weeks. 4 and 7 weeks after methyl parathion administration mononuclear cellinfiltration and glomerular atrophy were detected in the kidney tissues.Addition to this, necrotic areas were observed 7 weeks after. Also cellinfiltration and calcification were observed in Vitamin C+vitamin E+ methylparathion treated group 4 and 7 weeks after. No methyl parathion residue wasfound in the kidney tissue pesticides residue analyses 24hrs, 4 and 7 weeks aftermethyl parathion administration. As a result, lower doses of methyl parathioncaused histopathological changes in the rat kidney. Vitamin C and vitamin Ereduced damage occured in the kidney tissue. But they not protect completely.