MODY'nin moleküler patogenezinde miRNA analizi
2015
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Advisor: Prof. Dr. Arzu Karabay Korkmaz ; Doç. Dr. Ergül Berber
Abstract (EN)
Maturity onset diabetes of the young (MODY) is a monogenic form of Diabetes mellitus (DM) characterized with abnormal beta cell function, autosomal dominant inheritance, hyperglycemia, lack of auto-immunity in non-obese young patients. The prevalence of MODY changes with the population, but MODY3 associated with HNF1A gene mutations is the most common form of MODY. The main purpose of the study was to discover miRNAs that might be involved in the molecular pathogenesis of MODY by discovering the specific miRNAs that are regulated by HNF1A transcription factor.
Author
Dr. Oğuzhan Fatih Baltacı
Institution
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Oğuzhan Fatih Baltacı (Master Thesis). MODY'nin moleküler patogenezinde miRNA analizi, 2015, Istanbul Technical University.
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