Synthesis of 1,2,3 triazoles with click reaction in morpholin based 1,2,4 triazoles

In this study, at the first step 3-(alkyl/aryl)-4-(4-morpholino phenyl)-2,4-dihydro-5H-1,2,4-triazol-5-one (55) type 5 number original compounds are synthesized from the reaction of various hydrazine-1-carboxylate (53) type compounds with asunder 4-morpholine aniline (54). In continuation 3-(alkyl/aryl)-4-(4-morpholino phenyl)-2-(prop-2-yn-1-yl)-2,4-dihydro-5H-1,2,4-triazol-5-one (56) basis structure , 4 number original 56 type acetylenic 1,2,4-triazol compounds are synthesized from the reaction (4-morpholino phenyl)-2,4-dihydro-5H-1,2,4-triazol-5-one (55) compounds with probargyl bromide. On the next step, in the structure of 2-((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-3-alkyl/aryl-4-(4-morpholino phenyl)-2,4-dihydro-5H -1,2,4-triazol-5-one (57),4 number original 57 type 1,2,3 triazole kind compound is obtained from the " click" reaction (accompanied by catalyzer) of 56 type acetylenic 1,2,4- triazoles with 4-chlorobenzyl azide. In the last section of study, in basis form of 2-((1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-3-alkyl/aryl-4-(4-morpholino phenyl)-2,4-dihydro-5H-1,2,4-triazol-5-one (58), 3 number original 58 type 1,2,3-triazol kind compounds are synthesized from the "click" reaction (accompanied by catalyzer) of 56 type acetylenic 1,2,4 triazoles with 4-bromobenzyl azide, 58 type compounds with 4-bromobenzyl azide. It was detected that, shyntesized compounds own radical scavenging feature in substantial rate and radical formation inhibitive antioxidant property. Moreover, synthesized compounds demonstrate remarkable anti-bacterial and anti-fungual activities against 13 diffrent micro-organisms. It is determined, new compounds own inhibition feature over acetylcholin esterase enzyme in substantial rate. In the scope ofstudy, formation clarification of 16 number original compounds is done by using IR, 1H-NMR, 13C-NMR (APT) and LC-MS/MS.