Steroid-induced osteoporosis in nephrotic syndrome and its relationship to serum osteoprotegerin/RANK-ligand levels

Steroid-induced osteoporosis in nephrotic sndrome and its relationship toserum osteoprotegerin/RANK-ligand levelsAhmet AytekinThis study contains 21 patients and healthy control group which are followed anddiagnosed primer nephrotic syndrome from University of Gazi School of MedicineDepartment of Pediatrics and Child Health Department of Pediatric Nephrology.t was aimed that evaluated steroid induced osteoporosis with KMY, relationbetween osteoporosis and cumulative steroid dose, effected steroid treatment serum Ca, P,ALP, vitamin D, PTH, OC level and investigated OPG/RANK-L role in pathogenesis.t was no differance between patients (mean age 7.4 ± 3.1 years) and control groups(mean age 8.7 ± 1.9 years) in that age, genus, antropometric measurement. Beginning ageof disease 3.6 ± 3.1 years, its time 48.7 ± 39.7 months. Cummulative steroid dose wascalculated as 434.1 ± 300.1 (69.5-1124) mg/kg.Osteocalsin level was finding high while levels of total protein, albumin, Ca, P,ALP, 25-OH-D3, kidney function tests in the patients are normal limit. This finding isthought that increasing of bone building to get free bones from supressor steroid effect.Between serum OPG (according to circumstances 8,9 ± 3,9 and 7.9 ± 3.2 U/L, p>0.05) andRANK-L (according to circumtances 1337.2 ± 1479.6 and 1432.6 ± 1175 pg/ml, p>0.05)levels no statistical difference at the patients and control groups. KMY mean values patientmean spinal KMY values (0,599 ± 0,941 g/cm2 ) was paralel with same age normal meanspinal KMY values (0,504 ± 0,051g/cm2) at the Turkish child. Patients z score was normallimit however examine detail there was no osteoporosis while 4 patients was osteopeniaPatients were seperated two groups. 1. Take steroid two months and more 2. Tooksteroid and pasted three months and more. Between two groups there were no difference inthat cummulative steroid dose (p>0.05) and time (p>0.05). At the second group serum ALPlevels were very low statically when two groups compared (according to circumtances 233± 65 and 149 ± 59 U/L, p=0.008). Likely KMY was fixed very low according to didn?t takesteroid in this group (according to circumtances 0.634 ± 0.096 and 0.544 ± 0.06 p=0.025)This results is show that bone parameters increased later which decreased during steroidtreatment giving SDNS was able to using steroid daily following decreasing dose and everyother day. Finally steroid treatment is safely at the SDNS