Investigation of the antioxidant and anti-inflammatory effect of dexpanthenol in an experimental lung toxicity model generated with nicotine

Aim: Investigate the anti-inflammatory and antioxidant effects of Dexpanthenol in repairing the damage caused by nicotine in the lung tissue. Material and Method: 32 Spraque Dawley male rats weighing 250-300 grams, supplied from İnönü University Experimental Animal Production and Research Center, were used. Rats were randomly divided into 4 equal groups; The control group was divided into nicotine group, dexpanthenol group, dexpanthenol + nicotine group. For 8 weeks, Nicotine and Dexpanthenol groups were administered intraperitoneally (Nicotine 0.5mg/kg-day, Dexpanthenol 500 mg/kg/day). At the end of 8 weeks, lung tissue and blood samples of the rats were taken and biochemical and histological examinations were performed. Results: Nicotine administration increased oxidative stress parameters in the lung tissue of rats, MDA, TOS, OSI (P=0.002). It decreased antioxidant parameters (CAT, GSH-Px, SOD, GSH, GST). This situation caused histopathological conditions, caused inflammation in the lung tissue and caused an increase in IL-1β and IL-6 values, which are inflammatory factors. While dexpanthenol administration increased the level of antioxidant parameters in lung tissue, it caused decreases in oxidant (MDA) and serum inflammation values (IL-1β and IL-6). The application of dexpanthenol with nicotine tried to reduce the biochemical and histopathological effects of nicotine. Conclusion: Nicotine caused cell damage in the lung tissue, causing toxicity, and inflammations occurred. Dexpanthenol showed antioxidant and anti-inflammatory effects. Dexpanthenol can be added to the treatment protocol to treat the toxic effects of nicotine. Keywords: Lung, Dexpanthenol, Histopathology, Nicotine, Oxidative Stress Parameters, Rat