The effectiveness of using CPP-ACP in the treatment of white spot lesion

The aim of this clinical study is to investigate the effectiveness of fluoride varnish, CPP-ACP and CPP-ACP and fluoride varnish applications in addition to a standard remineralization protocol used for the white spot lesions development.21 children between the ages of 8-15 on a total of 101 tooth surfaces with white spot lesion treated for 12 weeks. The patients were randomly distributed into four groups. Control group was treated for a daily procedure of remineralization protocol including oral hygiene education, chlorhexidine mouthwash and chewing-gum with xylitol. In addition to the protocol of control group, second group had fluoride varnish, third had CPP-ACP and fourth had fluoride varnish with CPP-ACP. Before and after the remineralization protocols carried out, visual and DIAGNOdent Pen scores was recorded to compare the efficiency of all proceduresThe results of this study has shown that CPP-ACP with varnish or without varnish was significantly higher values in the success of visual examination (p <0.001 and p<0.001). In addition, CPP-ACP groups were determined significantly higher reduction in DIAGNOdent value.CPP-ACP itself seems to have an additional benefit to standard procedure and have a potential for treating white spot lesions in this short-term study.