Synthesis and characterization of organo sulfonate compounds

Organic substances containing the sulfonate motif are bioactive structural motifs frequently studied by researchers. It is known that organic molecules containing this motif have many biological activities such as antifungal, antineoplastic, antimicrobial, anticancer, enzyme inhibition, phytoremediation, anti-Oomycete, and insecticide. In our previous studies, new organic structures containing the sulfonate motif were successfully synthesized by our group and biological studies of these structures such as enzyme inhibition and phytoremediation were carried out. Ten new sulfonate derivatives expected to show biological activity were synthesized. The sulfonate derivatives (1-10) were analyzed and characterized by 1H NMR, 13C NMR, and HRMS. Firstly, 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one compound was obtained from 4-chlorobenzaldehyde and 1-(2-hydroxyphenyl)ethanone starting materials. Afterwards, new decorated organo sulfonate ester derivatives were obtained by using this compound with various sulfonyl chloride reagents.