Multiple dose antagoninst versus long lucrin protocol in ovulation stimulation of infertile patients over thirty-five years old

68 SUMMARY 72 patients, 35 years of age or over, who have applied to Gazi University Faculty of Medicine Obstetrics and Gynecology Department Contraception-İnfertility-Reproductive Health Center IVF Unit between January 2003-June 2004 with the complaint of infertility and accepted for IVF. Patients who fulfills inclusion criterias below has been taken randomly to our study. At COH protocol, GnRHAnt was used in 34 patients in the study group and GnRHa was used in 38 patients in the control group. Patient inclusion criterias were; under age of 35, day three basal FSH<10 IU/ml, basal E2<60 pg/ml, E2 value on hCG day in the previous cycle >500 pg/ml, >4 oocyte development in COH, both ovaries present, no previos ovarian surgery or cystectomy and no known diagnosis of advanced endometriosis. Clinical and epidemiological properties such as age, infertility period, cause of infertility, BMI, gravida, parity, abortus, ectopic pregnancy, basal FSH and estradiol levels have been evaluated. Each group has been compared by evaluating total gonadotropin dose used during COH or following embryo transfer, by the period of ovulation induction, by the number of days coasted, by the E2 level in the serum during 4-6, 7-8, 9-10, 11-12, 13-14 days of the induction, by the maximum E2 level, by the maximum LH level, by the number of follicles >=17 mm, 17-15 mm and 14-10 mm on the day of hCG, by the number of oocytes obtained by OPU, by the MJJ oocyte number obtained from the oocytes retrieved by OPU, by the number of oocytes undergone to ICSI, by the number of 2PN embryo, by the number of grade 1 and 2 embryo number checked on the third day of ICSI,by the number of embryo transfer, by the percentage of MU oocyte in the oocytes retrieved by OPU, by implantation rate, by69 fertilization rate, by cleavage rate, by pregnancy rate, by clinical pregnancy rate and by take- home baby rate. Significant results are summarized in table XVI. Table XVI: Results70 Results of our data were in favour of analogues in mean of 30 %, also these results reflected in analog group to pregnancy rate, but not statistically significant. Power analysis showed that analogue group should have 121 and antagonist group 148, overall 269 patients to be statistically significant. Pregnancy results are shown in table XVII. TabloXVII: Pregnancy Results NS:Not significiant