In situ applications of the palladium/ferrocenyl methylimidazolinium catalytic system in the Suzuki-Miyaura cross-coupling reaction

In this thesis study entitled "In Situ Applications of the Palladium/Ferrocenyl methylimidazolinium Catalytic System in the Suzuki-Miyaura Cross-Coupling Reaction", it was aimed to investigate the catalytic activities of imidazolinium salts containing ferrocene as auxiliary ligand in the presence of Pd(OAc)2 in Suzuki-Miyaura cross-coupling reactions. Firstly, synthesis of N,N′-bis(ferrocenylmethyl)imidazolinium chloride and/or bromide salts was carried out by our group in which synthesis and structure characterization were performed. After the synthesis of the salts, sample reactions were chosen to determine the optimum conditions for both Suzuki-Miyaura and Heck reactions. The optimum conditions for the Suzuki-Miyaura coupling reactions were obtained in the presence of K2CO3 at 80 °C for 24 hours, in the 1,4-dioxane solvent, when Pd(OAc)2 + N,N′-bis(ferrocenylmethyl)imidazolinium chloride salt was used as catalyst. The N,N'-bis(ferrocenylmethyl)imidazolinium chloride salt used as auxiliary ligand in the presence of Pd(OAc)2 and did not show a high catalytic activity in other selected reactions except Suzuki-Miyaura cross-coupling reaction between 4-bromoacetophenone and phenylboronic acid.