Clinical and radiographical evaluation of hyaluronic acid and bovine derived xenograft combination versus bovine derived xenograft alone

The aim of the present study was to compare the clinical and radiographical effects of a new biomaterial including hyaluronic acid (HA) and bovine derived xenograft (BDX) combination versus BDX alone application in the treatment of periodontal intrabony defects of advanced chronic periodontitis patients. Twenty advanced chronic periodontitis patients who had intrabony component of ≥3 mm and radioghraphical intrabony defects with an associated probing depth (PD) of ≥5 mm were included. A total of 54 intrabony defects were surgically treated with HA+BDX combination (group 1) whereas 55 intrabony defects were treated with BDX alone (group 2). Plaque and sulcus bleeding indices, PD, marginal recession, relative attachment and bone levels and radiographic bone levels were recorded at baseline and 12 months after surgery. Healing was uneventful in all cases. At 12 months postoperatively, intragroup comparisons revealed statistically significant differences compared to baseline for all evaluated clinical and radiographical parameters (p<0.05). Considering the deepest site of the defects, group 1 and 2 showed a mean PD reduction of 3.38±1.29 mm and 2.99±0.75 mm, attachment gain of 2.56±1.26 mm and 2.33±0.57 mm, recession of 0.79±0.88 mm and 0.66±0.56 mm, clinical bone gain of 2.39±1.45 mm and 2.09±0.65 mm and radiographic bone gain of 2.28±1.34 mm and 1.93±0.95 mm, respectively. Intergroup comparisons for all parameters were found to be insignificant (p>0.05). Within the limits of this study, it can be concluded that both HA+BDX and BDX applications led to significantly favourable clinical improvements in intrabony periodontal defects compared to baseline. No statistically significant differences in any of the investigated parameters were observed between the groups. Key words: Hyaluronic Acid, Bovine Derived Xenograft, Intrabony Defect, Chronic Periodontitis