The synthesis and applications of biocompatible polyurethane tissue adhesives based on polyphenol

Tissue adhesives are biomaterials providing support in prevention of problems in clinical surgery. In this thesis content, the synthesis, characterization and in vitro and in vivo application of strong sealable and biocompatible polyurethane tissue adhesives were carried out using polyphenols such as caffeic acid, catechol, protocatechuic acid ethyl ester and chlorogenic acid as natural polyols source, polyethylene glycol (PEG200) and aliphatic diisocyanates (hexamethylene diisocyanate, isophorone diisocyanate, 4,4'-diisocyanodicyclohexylmethane). Synthesized polyurethanes were examined by FTIR, NMR, TGA, DTA, DSC, elemental analysis and contact angle of water in terms of structure. The highest adhesion strength was determined as 459.6±86.8 kPa for NPU-PEG-C in adhesion strength test for synthesized poliphenol-based polyurethanes. At the end of 8 weeks, biodegrability was identified at range of 15-30% in biodegradability tests. The protein adsorpsion levels of synthesized polyurethanes were determined at the range of 15-55 µg BSA/cm2 ve 10-40 µg fibrinojen/cm2. In in vitro biocompatibility test. All polyurethanes showed at high cell viability with the value of above 85% on RAOEC cells in in vitro biocompatibilty test. In addition to, obtained histological and biochemicial data from in vivo biocompatibilty test were identified to be quite parallel with cell viability results. As a result of, the polyphenol-based polyurethane tissue adhesives were developed with high adhesion strength, biodegredable, in vitro and in vivo biocompatible properties.