The effect of curcumin or white bean extract on biochemical and anthropometric parameters in women with polycystic ovary syndrome

This study was planned to investigate the effects of personal diet therapy with curcumin or white bean extract (Phaseoleus vulgaris) on anthropometric measurements and some biochemical parameters in patients with polycystic ovary syndrome (PCOS). The study was conducted on 45 diagnosed volunteer PCOS patients who are divided into 3 groups. During 8 weeks period, the first group (n=15) was treated with the combination of curcumin extract and weight loss diet, the second group (n=15) was treated with the combination of white bean extract and weight loss diet, the third group (n=15) was treated only weight loss diet. According to the evaluation of weight loss target (2-5% of the body weight), all groups are similar. After 8 weeks all groups have significant decreases in BMI, waist and hip circumferences and body fat mass (p<0.05). Between anthropometric measurements of groups have significant reduction in waist/hip ratio after 8 weeks. 3rd group has the highest reduction ratio with 18%. After 8 week, the body analyze of groups were not different. The biochemical analyzes between groups at 8th week, there were significant difference in LH, SHBG, TG, CRP, fasting insülin ve HOMA-IR (p<0.05). Between groups, 1st group has the most decrease in CRP; 2nd group has the most decrease in fasting insülin,TG and HOMA; 3rd group has the most increase in SHBG and LH. This results are positive effects for PCOS treatment but increases in LH of 2nd group and in CRP of 3rd group does not mean positive. This method of this study is the fist one in PCOS so longer studies should be investigated for the benefit of treatment. Keywords:,Curcumin, diet therapy, PCOS, Phaseolus vulgaris, white bean extract.