Evaluation of the relationship between immune system and endocrine system in children diagnosed with polycystic ovary syndrome

Polycystic ovary syndrome is the most common endocrinological disease in women of reproductive age. Although it is thought that pathologies such as insulin resistance, chronic low-level inflammation and hyperandrogenism are central theme of the disease, the exact pathophysiology of the disease has not been fully understood. This study's aim is to reveal the relationship between routine endocrinological and immunological markers related to chronic inflammation, and to investigate the place of these values in the diagnosis, management and treatment of the disease. 32 PCOS patients who consulted to Gaziantep University Sahinbey Training and Research Hospital Pediatric Endocrinology and Metabolism clinic and 39 healthy girls who consulted to the General Pediatric clinic were included in this study. Apart from anthropometric measurements, lymphocyte subsets were studied from both groups. The lipid profile, FSH, LH, testosterone, estrogen, glucose, insulin, HOMA score, ACTH, cortisol, AMH, DHEA-S and thyroid function tests results of the patient group were compared with reference values. Compared to the control group, PCOS patients had significantly decreased CD8+ and CD16/56+ percentages (p=0,037 ve p=0,001), and increased AMH and HOMA score. In the patient group, it was found that CD3+ percentage and estrogen hormone had positive correlation (p=0,023), while CD4+ percentage had negative correlation with LDL, triglyceride and AMH (p=0,01, p=0,038 ve p=0,005). In addition, a negative correlation was observed between 17-OH progesterone, DHEA-S and the percentage of HLA-DR+ (p=0,008 ve p=0,023). As a result, PCOS is not only a disease with an endocrinological basis, but also a complex case that many different pathologies play a role, especially immune dysregulation, in its pathophysiology.