Evaluation of Systemic Immuno-Inflammation Indices in Retinopathy of Prematurity Prognosis

Purpose: To evaluate Systemic Immuno-Inflammation Indices and ROP prognosis. Methods: Retrospective study. This study included 109 patients with premature birth (≤32 weeks gestational age) and/or low birth weight (≤1500 g) at Hacettepe Hospital between January 1, 2020 and January 1, 2024. Serum neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were calculated at birth and one month after birth. The relationship between ROP development, treatment requirement and systemic immuno-inflammation indices was analyzed. Results: Infants participating in the study were divided into three groups: without ROP (n = 32), ROP but not requiring treatment (n = 55), and ROP requiring treatment (n = 21). First month NLR, LMR, SII and SIRI were significantly associated with ROP development (OR: 3.548, p = 0.01), (OR: 0.706, p = 0.001), (OR: 1.003, p = 0.028), (OR: 1.559, p = 0.03) respectively and NLR, SII and SIRI were found to be risk factors in treatment required patients (OR: 2.70, p = 0.004), (OR: 1.003, p = 0.01), (OR: 1.366, p = 0.004). Conclusion: Postnatal first month NLR, SII and SIRI values were found to be statistically significant risk factors for development and treatment requirement in retinopathy of prematurity. Further studies are needed for its clinical application.