The effect of two different 8-week walking programs, tumor necrosis factor-alpha (TNF-α), fetuin-A (α2 - Heremans Schmid Glikoproteini, Ahsg) , c-Jun N-terminal kinase1 (JNK-1) and retinol-binding protein-4 (RBP4) the markers of endoplasmic reticulum stres in pre-menopausal women.

The aim of this study is to investigate the effect of two different 8-week walking programs on the body composition, MaxVO2 and TNF-α, Fetuin-A, JNK-1 ve RBP4, the markers of endoplasmic reticulum stres in pre-menopausal women. Thirty five healthy sedentary women aged 35-45 years and living in İzmir region participated in the study and were divided into three groups as moderate tempo walking group (MTWG; n=11), brisk walking group (BWG; n=12) and control group (CG; n= 12). Exercise groups walked for eight weeks, five days per week from 30 min per day steadily increasing up to 51 minutes. BWG walked at the intensity of 70% maximal heart rate reserve (HRRmax) for 30,33,36 and 39 minutes for the first four weeks. They walked for 42,45,48 and 51 minutes at the intensity of 75% HRRmax for the second four weeks. MTWG walked the same durations at the intensity of 50% HRRmax for the first four weeks, and at the intensity of 55% HRRmax for the second four weeks. Body composition, MaxVO2, TNF-α, Fetuin-A, JNK-1 ve RBP4 levels of all participants were measured before and after the study. At the end of the 8-week training programs, more significant changes were observed in body composition measurements (body weight, lean body weight, body fat percent, fat weight, body mass index) and MaxVO2 in BWG compared to MTWG, favoring BWG. Due to the changes favoring BWG in terms of MaxVO2, an important fitness index, body composition measurements and some of the endoplasmic reticulum stres markers – TNF-α, JNK-1 ve RBP4 –that have recently been discovered and the functions and the relationships with the physical exercise of which have not thoroughly been explained, brisk walking exercises are advisable since they are thought to be more effective in preventing obesity and cardiovascular diseases.