Retrospective investigaton of long-term results after transplant in patients with liver transplant due to primary sclerosing colangitisretrospective investigaton of long-term results after transplant in patients with liver transplant due to primary sclerosing colangitis

Introduction: Liver transplantation is the treatment of choice for patients with advanced liver disease due to primary sclerosing cholangitis (PSC). The aim of our study is to retrospectively investigate the long-term results after transplantation in patients who underwent liver transplantation due to PSC. Material and Methods: Patients who underwent liver transplantation due to Primary Sclerosing Cholangitis between February 2008 and October 2020 in the Department of Gastroenterology of İnönü University Faculty of Medicine were included in the study. The patients' age, gender, transplant types, life expectancy, post-transplantation biliary complications, rejection and recurrence rates were investigated. Results: There were 30 patients, 18 male and 12 female, who underwent liver transplantation due to PSC. Live transplant in 27 of the patients (90%); Cadaveric transplantation was performed in 3 (10%). The 1, 3, and 5-year survival rates in patients transplanted due to PSC, respectively; We found 75.9%, 74.9% and 74.9%. Biliary complications were detected in 50% of the patients, PSC recurrence in 13.3%, and chronic rejection in 10%. Surgical treatment was not applied to any of the patients due to biliary complications. All patients with biliary complications were successfully treated with endoscopic and percutaneous treatment methods. Conclusion: Liver transplantation remains the only curative treatment option in PSC patients, with high post-transplant survival rates. Post-transplant patients should be followed closely, especially in terms of biliary complications. Keywords: Primary sclerosing cholangitis, liver transplantation, biliary complication