Investigation of preptin and amylin levels in patients with psoriasis vulgaris and behcet disease

Psoriasis is the most frequent type in the chronical inflammatory diseases. Many genetic and environmental factors play a significant role in etiopathogenesis of psoriasis. Behcet disease is a chronical, recurrent, systemic vasculitis. The etiology and pathogenesis of Behcet disease is not known completely.It is suggested that inflammation, which is seen in the diseases of psoriasis and Behcet, causes a rise in insulin resistance and metabolic syndrome disorder.Preptin and amylin are peptids related to insulin resistance, and they are released with insulin in islet-cells of pancreas. In this study, it was aimed to investigate the relation of preptin and amylin to the psoriasis, Behcet diesease and metabolic syndrome, independently free from obesity.Thirty patients with psoriasis and 30 patients with Behcet disease and 30 healthy people as control group were taken to this study. The levels of fasting blood glucose, trigliserid, LDL, VLDL, HDL, total cholesterol, HbA1c, C-peptid, insulin, serum preptin and amylin of all participants were measured. In addition, body mass index, waist circumference, blood pressure measurements of patient groups and control group were done and values of HOMA-IR were calculated.The serum preptin level of psoriasis and Behcet patients was found as significantly lower than the level of the control group ( respectively, p<0.001, p=0.004). The serum amylin levels of psoriasis and Behcet patients were found as significantly lower than the level of the control group ( respectively, p=0.004 and 0.008). There was no important difference in terms of level of serum preptin and amylin between the patients with Behcet and psoriasis( p>0.05). The serum insulin level and HOMA-IR index of psoriasis patients group were found as significantly lower than control group ( respectively, p=0.02, p=0.03 ).Eight psoriasis patients (%26.7), five Behcet patients (%16.7) had metabolic syndrome. Serum preptin level of patients with metabolic syndrome was found as significantly lower than the non-metabolic syndrome patients.In conclusion, in this study, we determinated that serum preptin and amylin levels were lower in patients with psoriasis and Behcet compared to healthy controls. viWe think that preptin and amylin levels are not associated with psoriasis and Behcet disease, but may be they are associated with metabolic syndrome.Keywords: Psoriasis, Behçet disease, insulin resistance, preptin, amylin