Investigation of the relationship between methyl arginines levels and heat shock proteins in patients with psoriasis

This study aimed to investigate the levels of methylarginine derivatives (ADMA, SDMA, LNMMA) and nitric oxide pathway-related parameters, as well as the heat shock proteins HSP60, HSP70, and HSP90 in patients with psoriasis, and to evaluate the roles of these parameters in the pathogenesis of the disease. Conducted on a sample of 45 psoriasis patients and 45 healthy individuals admitted to the Dermatology Outpatient Clinic of Selçuk University Hospital, serum levels of ADMA, SDMA, and LNMMA were measured using LC-MS/MS, while HSP60, HSP70, and HSP90 levels were determined using ELISA. The findings revealed that HSP60 levels were significantly lower in the patient group, whereas HSP70 and HSP90 levels did not differ significantly between groups. Additionally, ADMA, SDMA, LNMMA, arginine, and citrulline levels were significantly lower in psoriasis patients compared to healthy controls. Correlation analyses demonstrated a positive and significant relationship between HSP60 and HSP70 levels in the control group and between HSP60 and HSP90 levels in the patient group. These results suggest that both cellular stress response and nitric oxide pathway regulation are intricately modulated in psoriasis, and that HSP60 and methylarginine derivatives may serve as potential biomarkers in the biological assessment of the disease. Keywords: Psoriasis, HSP60, HSP70, HSP90, ADMA, Nitric Oxide