Surgical margin status predictors at patients who underwent radical prostatectomy

Surgical Margin Status Predictors at Patients who Underwent Radical Prostatectomy Introduction and Purpose: Positive surgical margin is an unwanted pathological outcome at patients who underwent radical prostatectomy. There are numerous studies in the literature on other variables associated with poor prognosis in prostate cancer, such as gleason score and stage, and the relationship between these variables and patient values that can be measured preoperatively but there are limited number of studies regarding the preoperative prediction of the surgical marginal status. The aim of our study was to investigate the predictive value of preoperative patient characteristics and laboratory values for surgical margin status. Materials and Methods: We included 173 patients who underwent radical prostatectomy between January 2011 and October 2017 in the study. Patients' medical histories were scanned retrospectively and age, body mass index (BMI), preoperative PSA, preoperative gleason score, number of positive cores, percentage of tumor in positive cores, prostate volume, neutrophil lymphocyte ratio (NLR), AST / ALT ratio (de ritis ratio), presence of preoperative erectile dysfunction, clinical T stage, pathological T stage, postoperative gleason score, postoperative tumor percentage, seminal vesicle invasion, extraprostatic spread, perineural invasion, lymphovascular invasion and lymph node metastasis were recorded and compared with surgical margin status. Results: In our study, it was determined that BMI, number of positive cores, percentage of tumor in positive cores, de ritis ratio, preoperative gleason score and clinical T stage were statistically significantly different between the surgical margin positive group and negative group. Positive surgical margin risk increased by 3,3 times in patients who have 2,5 and higher NLR values compared to patients who have NLR lower than 2,5. In addition, positive surgical margin risk increased by 8,9 times in patients who have 4 + 4 and higher gleason score compared to patients who have 3 + 3 and lower gleason score. It was found that increase in BMI and number of positive cores significantly increases positive surgical margin risk. Conclusion: In our study, it was determined that BMI, number of positive cores, NLR and preoperative gleason score were predictive value for surgical margin status.