Effect of methyl parathion the rat small intestine and protective role of vitamin C and E

Methyl parathion, an organophosphorous insecticide, is widely used inagricultural control and causes poisoning. In the present study, methylparathion (0,28 mg/kg day), vitamin C (200mg/kg day) + vitamin E(200 mg/kgday), vitamin C (200mg/kg day) + vitamin E (200 mg/kg day) + methylparathion (0,28 mg/kg day) were given to male rats through gavage. Bodyweight of the rats were weightened, histopathological changes were investigatedusing light microscope 24 hrs, 4 and 7 weeks after administration. Nostatistically significant changes of body weight were observed in methylparathion treated group and vitamin C + vitamin E + methyl parathion treatedgroup 24 hrs after, statistically significant decrease were observed after 4 and 7weeks. After 4 and 7 weeks of methyl parathion exposure, dilatation wasobserved in intestinal villi. Addition to this, infiltration in some area wasobserved 7 weeks after. After 4 and 7 weeks of vitamins C + vitamin E + methylparathion exposure, degenerative changes were detected in the intestinal villi.As a result, lower doses of methyl parathion caused histopathological changes inthe rat small intestine. It?s determined that vitamin C and vitamin E haven?tprevented the pathological changes caused by methyl parathion in smallintestine.