Saliva antigen test as anew biomarker in population-based screening of coronavirus infection

Saliva testing is becoming more common. It contains salivary gland secretions, desquamated oral epithelial cells, and microorganisms. There are also immunoglobulins, mucins, enzymes, metabolites, hormones, and electrolytes. This makes saliva ideal for early covid 19 diagnosis. This study examines oral specimens and compares SARS-CoV-19 antigen detection assay results with CRP and other markers. Cross-sectional study of 19 covids. 100 patients with a full history, exam, and covid19 lab tests provided blood and saliva. PCL COVID19 Ag (saliva test) detects SARS-CoV19 antigen in human saliva. Diagnostic accuracy for SARS-CoV-2 in blood and saliva varied. The CRP test found 79% in group1 and 66% in group2, while the saliva test found 6% and 7%. D-dimer tests found 80% in group1 and 76% in group2. PCL SARSCoV-2 saliva antigen test accuracy in early/late infection was below manufacturer specifications. Remember this when testing. DIAGNOS may be an easy-to-use saliva complement to detect SARS-CoV-2 positive individuals, but validation with other biomarkers and diagnostic tools using larger sample sets is needed. Keywords: Saliva antigen test, Biomarker, Coronavirus, Infections