Sıçanlarda aralıklı açlığın ve susuzluğun iskemi-reperfüzyon ile uyarılan aritmiler üzerine etkisi

Ischemia and reperfusion induced arrhythmias such as ventricular tachycardia or ventricular fibrillation are one of the most important causes of death in myocardial ischemia. That is why, it is important to find factors increasing resistance against myocardial ischemia induced by sudden occlusion of coronaries in human being. The changing of life style or feeding habit may be more effective in the reduction or prevention of death from cardiovascular disease instead of using drug. Dietary restriction, including caloric restriction, intermittent fasting or alternative day fasting may be protective in the decreasing the incidence of death due to the coronary artery disease in human being. Recently, researchers have focused on the various effects of intermittent fasting. It has been shown that intermittent fasting can reduce cardiovascular disease. In literature, there could not found any research related with the effect of both intermittent fasting and water restriction on the ischemia and reperfusion induced arrhythmias in rats. Thirty male rats in 8-9 months old were used in this study. Six minutes ischemia was produced by ligation of left coronary artery which was followed by six minute reperfusion by releasing of this artery. Control group was fed ad libitum. IFW1 group was subjected to intermittent fasting and water restriction for one month. IFW2 group was maintained one month intermittent fasting and water restriction followed by one month normal feeding.ECG and arterial blood pressure were recorded during ischemia and reperfusion. Blood glucose level was also measured before ligation. The blood pressure and heart rate during ischemia and reperfusion did not show a significant difference among groups. Similarly, there was no significant difference in arrhythmia score calculated from duration and type of arrhythmia. But arrhythmic period during ischemia in IFW1 was longer in respect to other groups. Blood glucose level significantly decreased in animals maintained on food and water intermitted restriction. In conclusion, it was found that the intermittent fasting and water restriction that is experimental model of Ramadan fasting did not have any effect on the severity of arrhythmia induced by ischemia and reperfusion. Further studies should be made to research the effect of other restriction models on the ischemia or reperfusion induced arrhythmia and the survival rate of animals after acute coronary artery occlusion.