In vitro gentoxic effects of Cd(8Q)2(SCN)2 schiff base complex

In this study, chromosomal abberation and micronucleus tests were used to determine in vitro genotoxic effects occuring on human peripheral lymphocytes by Cd(8Q)2(SCN)2 with schiff base complex as synthesized drug raw material for research .In the results of reseach explored with 1, 2, 4, 6, and 8 µg/ml doses, in chromosomal abberation test applied with 24 h perioud, doses as from 4 µg/ml were observed significantly increase from controls when in chromosomal abberation test applied with 48 h perioud, doses as from 2 µg/ml were observed significantly rise from controls at both chromosomal abberation frequency and abnormal cell percentageIn the micronucleus test applied 48 h period, 4 µg/ml dose were detected significantly difference from negatif control. In the application which was made with 48 h period due to being cytotoxicity effects of 6 and 8 µg/ml doses on human peripheral lymphocytes the cell proliferations decreased and data was not got from these doses.