Sirtuin 1, 2 ve 7'nin plasenta akreta patogenezindeki rollerinin araştırılması

The Placenta Accreta Spectrum (PAS) is defined as the adhesion of the placenta to the uterine wall to varying degrees. The normal placenta does not pass beyond one-third of the myometrium, but the invasive placenta acts in a similar way to a malignant tumor, multiplying its local structures and invading the myometrium. Uterine scar, history of cesarean section, and presence of placenta previa are considered the clinical risk factors, but studies on the molecular mechanisms responsible in PAS are very limited. It is known that SIRT1, 2, and 7 affect epithelial plasticity by reprogramming EMT, leading to invasion and metastasis. Although EMT's marker levels are high in PAS, there are no studies on the role of SIRT1, 2, and 7 in the pathogenesis of the disease. For this purpose, 30 PAS, 30 PPT, and 30 controls were included in our study. The expression levels of SIRT1, 2, and 7 in the placentas of these groups were determined by the western blot method. Serum levels of SIRT1, 2, and 7 in maternal and fetal cord blood were determined by the ELISA. The localization of SIRT1, 2, and 7 in the placental tissues of the patient and control groups were determined by immunohistochemical staining. In our studies, we found that SIRT1 and SIRT7 were significantly lower in PAS compared to the control in placentas, while SIRT1, 2 and 7 levels in serum samples were not significantly different when compared between the 3 groups. In conclusion, our results suggest that SIRTs may play an important role in the pathogenesis of the PAS in the aspect of contribution to invasiveness features.