Erbil hapishanesindeki agresif suçlularda Monoamine oxidize a gen mutasyonlarının araştırılması

The aim of this study was to investigate the association between the mutation of exon 8 of monoamine oxidize A gene (MAOA) genes and aggressive behavior in criminals in the prison of Erbil city Kurdistan region- Iraq. To achieve this aim, blood sample were collected from 30 prisoners and 5 control group, their age ranged from 21 to 60 years. This work also used molecular approaches to investigate the mutation of exon 8 MAOA gene in criminals. DNA analysis performed using DNA extraction, PCR amplification, gel electrophoresis and sequence analysis. The following result could be considered; a young offenders crime peaks between the ages of 21 to 30 and offending rates of 31 to 40 aged group decline sharply with age. Most of the cases were failed in the education system and have no formal higher school qualifications. Most of them had regularly truanted from school and 16 out of 30 cases (53%) had formal qualifications primary while 11 (36%) had formal qualifications secondary school. The correlation between marriage and crime high for 25 (83%) cases of married but only 5 out of 30 (17%) was single. In direct DNA sequence analysis in the exon 8 in MOAO gene, we observed two mutations substitution and insertion. The result show common mutation in exon 8 type of mutation in exon 8 of MAOA gene of criminals. The percentage of common mutation in exon 8 was 52% by substitution at position 2326 nt of exon 8, that SNP (G-T) change arginine to arginine (nonsense mutation) and 26% G to C transversion at nucleotide position 2276 change lysine to asparagine (missense mutation) and 4% insertion (C) at position 2302 change frame shift change all amino acid downstream. Keywords: MAOA gene, criminal state, Erbil.