Synthesis and characterization of new acridine derivatives of the substituted pyrazol-4-carbaldehyde

Acridine is a synthetic molecule that has a synthetic ring system and is used in the synthesis of dyes and some valuable drugs. Pyrazole is a five-membered heterocyclic ring system consisting of three carbon atoms and two nitrogen atoms side by side. In the literature, it is possible to find many studies that the chemical compounds carrying the pyrazole nucleus have a significant potential on the central nervous system. This study, aims to synthesize and characterize newly designed pyrazole-acridine compounds, which may have the potential for various biological activities. For this, the starting compound 3- (4-nitrophenyl) -1-phenyl-1H-pyrazole-4-carbaldehyde was synthesized according to the literature. The resulting compound was cycled with 5,5-dimethylcyclohexane-1,3-dione (β-diketone) and various aromatic amines to yield new pyrazole-acridine derivatives containing different biologically active groups. Structures of the compounds we synthesized were screened using FT-IR, 1H-NMR, 13C-NMR and mass spectral data.