Examination of the effect of curcumin in experimental liver damage created by diethylnitrosamine in swiss albino mice to superoxide dismutase and catalase activities and glutathione, malandialdehyde, and advanced oxidation protein products levels

In this study, the effects of curcumin, reduced glutathione (GSH), malondialdehyde (MDA) levels, advanced protein oxidation products (AOPP), superoxide dismutase (SOD) and catalase (CAT) activities in experimentalliver damage with diethylnitrosamine (DEN) in Swiss albino mice were investigated. Subjects (n=9) were divided into 5 as damage control 1, damage control 2, curcumin preservative and treatment, and healthy controlgroup. Curcumin oral gavage (in 150 mg/kg of ethylalcohol) was given to the protecting group for 19 days, 5 days before the administration of Diethylnitrosamine, and 24 hours after the administration of Diethylnitrosamine. 100 µl of ethylalcohol oral gavage was given to the healthy group for 19 days. While MDA levels decreased significantly in the curcumin preservative group (p<0.05) (p=0.002), the decrease was not significant in the treatment groups (p>0.05), (p=0.128). AOPP levels decreased significantly in the curcumin protective group (p<0.05) (p=0.009) but the decrease in the treatment group was not found significant (p>0.05), (p=0.073). SOD activities increased significantly in both groups. It was found as (p<0.05), (p=0.001) and (p<0.05), (p=0.002), respectively. Reduced GSH levels decreased but these reductions were not found statistically significant.CAT activities increased significantly in both groups. It was determined as (p<0.05), (p=0.001) for both groups. Keywords: Curcumin, Diethylnitrosamine (DEN), Liver Cancer