Synthesis, characterization and antimicrobial studies of dopamine-related sulfonamide derivatives

N-[4-(pyrimidinylsulfamoyl)phenyl] propionamide dopamine-related sufonamide derivatives were synthesized. These compounds were prepared from the a nucleophilic addition/elimination reaction of 3-(3,4,5-trimethoxyphenyl)propionic acid with various sulfonamides. The sulfonamides used were used were sulfadiazine, sulfamonomethoxine and sulfadimethoxine. Sulfonamides derivative are well known for their antimicrobial activities, especially in the treatment of malarial infections and are often taken with other sulfonamide drugs, such as, the antimalarial agent pyrimethamine. Drug combinations are preferred method of approach for combating antimicrobial infections. The goal of this research was to synthesize a single compound for the effective use against microbial diseases for improved drug applications. The chemical structures of the synthesized compounds were characterized by Elemental Analysis, 1H and 13C NMR Nuclear Magnetic Resonance Spectroscopy (NMR), Liquid Chromatography-Mass-Mass Spectroscopy (LC-MS-MS), Ultraviolet-Visible Spectroscopy (UV-Vis), Fourier Transform Infrared Spectroscopy (FTIR) and Photoluminescence (PL). The dopamıne-related sulfonamide derıvatıves derivatives synthesized were evaluated for antimicrobial activities.