Synthesis of substituted quinazolinones by using N-(2-Aminobenzoyl)benzotriazoles in one-pot reaction

N-Heterocyclic compounds are very important organic compounds because they are widely used in medicine, pharmacy, bioengineering. Especially in the pharmaceutical industry and in medical chemistry, it is of great importance for drug synthesis and treatment of diseases. The synthesis of these compounds and the examination of their biological activity is one of the major study topics of synthetic organic chemists. The quinazolinone ring is present in the structure of about 150 alkaloids and drug. The naturally occurring and synthesized quinazolinone derivatives have many biological and pharmacological effects such as antifungal, antimalarial, antihyperlipidemic, anticonvulsant, anticancer. In this thesis, substituted quinazolinones are aimed to be synthesized in a one-pot reaction by treating the N-(2-aminobenzoyl)benzotriazole compounds with ammonium acetate, various primary amines, hydrazides, orthoesters and aldehydes.