The value of thymosin beta 4 and cardiotrophin 1 concentrations in acute coronary syndrome risk classification

ABSTRACT Coronary artery diseases are currently leading tha main cause of mortality and morbidity in our country as in the world. Many risk classifications were defined for reducing the acute coronary syndrome (ACS) patients mortality rate. But we need new risc indicator to reduce high rate mortality in ACS patients. In our study, we want to measure cardiotropin-1 (CT-1) and thymosin beta4 (Tb4) levels in ACS patients. Finally we aimed to show correlation between Tb4,CT-1 and classic risk classifications. This study include 177 patients (male:139, female:38) who were diagnosed and treated for ACS in the Faculty of Duzce University between Desember 2011- Desember 2012. Patients' clinical and electrocardiographic findings, laboratory results were recorded when the patients admitted to hospital. As soon as the appropriate intervention and medical treatment was done. The classic risk points measured carefully. CT-1 and Tb4 levels were measured from blood sample between 12-24 hours after admission to hospital. Death, revascularition and serebrovascular events were defined major advers events and major adverse events were determined after six months following. And finally, we compare the relationships between CT-1 and Tb4 levels, classic risk classifications and the results of six months following. The diagnosis include all types of acut coronary syndrome. 20 patients (%11); unstabil angina, 52 patients (%29); non-st elevation miyocardial infarction, 107 patients (%60;) st elevation miyocardial infarction. CT-1 and Tb4 levels were not significantly different between these three groups. CT-1 and Tb4 levels are compared to patients' risk scores. Only the left ventricul ejection fraction levels were showed weak inverse signficant correlation between CT-1 (p = 0,049, r = -0,17). Syntax , Euroscore ,TIMI and GRACE points were not significantly correlated between CT-1 and Tb4. After the evaluation CT-1 and Tb4 levels were not become independent risk for major adverse events. This study showed that these biomarkers have not a prognostic value for ACS patients during in hospital and long-term follow-up. Key words: Acute coronary syndrome, Cardiotrophin 1, Thymosin Beta4