Gelsolin, adipsin and taurine levels in plasma and urine as an early indicator of diabetic nephropathy in children with TYPE 1 diabetes mellitus

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia caused by insulin secretion or the effect of insulin on tissues, or both. Urine microalbumin is currently the most valuable parameter for the diagnosis of diabetic nephropathy (DN). In this study, we aimed to investigate the usability of Neutrophil gelatinase-associated lipocalin (NGAL), Taurine, Gelsolin and Adipsin levels in the early diagnosis of diabetic nephropathy by measuring these parameters in the plasma and urine of healthy controls and type 1 diabetic patients with and without microalbuminuria. In this study, 50 pediatric patients with type 1 diabetes mellitus (HbA1C> 6.5%, fasting blood glucose ≥126 mg/dl, postprandial blood glucose ≥200 mg/dl) who were followed up at the Pediatric Endocrine Outpatient Clinic of Fırat University Hospital between the ages of 5 and 18 years were evaluated. 30 healthy children without diabetes who applied to the general pediatric outpatient clinic of Fırat University Hospital for routine follow-up were selected as the control group. Biochemical parameters of these groups were obtained from hospital records. In addition, 5 ml blood and 10 ml urine samples were taken simultaneously. Gelsolin, adipsin, taurine and NGAL levels were studied in biological samples. Consistent with the literature, urinary and plasma NGAL levels were significantly higher in children with Type 1 DM than in the control group. In children with type 1 DM, taurine and gelsolin levels were significantly lower in plasma and urine compared to the control group. Adipsin was lower in the plasma of children with Type 1 DM compared to the control group, whereas there was no significant difference in urine adipsin levels between the two groups. According to the results, increasing NGAL, decreasing taurine and gelsolin are important markers in the diagnosis of DN, and since these parameters show a parallel with urine; we think that urine is going to be an important biological fluid (urine) in the diagnosis and follow-up of DN for patient comfort (not invasive). Keywords: Adipsin, diabetic nephropathy, gelsolin, NGAL, taurine,