Microwave assistant synthesis of new bisbenzimidazoles containing triazole and thiadizaole derivatives and investigation of their some biological activities

Bisbenzimidazole compounds have gained importance in recent years owing to properties of their enhanced to link to DNA and nucleic acids homopolymers with different functional groups which have been in benzimidazole structure by electronic effects, thermal denaturation and viscosity methods. At first stage of this study, bisbenzimidazole derivatives were synthesized from different starting materials. At the second stage, ester compounds were yielded via acidic proton substituted N-3 nitrogen of this compound with substitution reaction in the presence of ethyl bromoacetate. Hydrazide compounds were obtained from ester compounds in the presence of hydrazine hydrate by hydrazination reaction. The next step, hydrazide compounds were reacted with phenyl and benzyl isothiocyanate, obtained to carbothioamide derivatives. All reactions were utilized by both microwave-assisted and conventional methods for comparing yields and reaction time. Finally, thiadiazole derivatives obtained under acidic conditions and triazole derivatives obtained under basic conditions from carbothioamide derivatives with ring closure reactions, respectively. Totally, 16 novel compounds were synthesized with in this study. All compounds obtained in this study were also investigated for antimicrobial, anti-lipase and anti-glucosidase activities. All structures of the obtained compounds were characterized by using spectroscopic techniques like IR, 1H-NMR, 13C-NMR, and mass spectroscopy.