The association of presenilin-2 gene with alzhemieris disease in Turkish population

Presenilin-2 is one of thecausativegenesforfamilialAlzheimer'sdisease (FAD). Thepurposeof thiscase-controlstudywastodeterminewhether SAD is associatedwiththe PSEN2 gene polymorphism in a Turkishpopulation. WeexaminedPSEN2 genotypes in 180 SAD patientsand an equalnumber of age- andsex-matchedcontrolsfromthesamecommunity, usingthe PCR?RFLP method. AllelicandgenotypicdistributionswereperformedusingthePearsonChi-squaretest andHardy-WeinbergEquilibriumtest forhomogeneity.Alsoweuseoddrationfor risk of AD. Theresultsrevealedsignificantdifferences in thefrequency of the +A/?A polymorphismbetween AD andcontrols. normal genotype of patientsration is%26,3 ,whereas anormal genotype of patientration is %73,7. There is a properlyassociationbetweenresult of genotypewithstateofhealth(p<0,05).People`s risk of morbidity; patientswhohave anormal genotypeare 4.40 foldmorethanpatientswhohave normal genotype(%95).