The relationship of C-reactive protein/albumin ratio with endoscopic and mucosal activity in patients with ulcerative colitis

Introduction: In this study, it was aimed to retrospectively evaluate the relationship between C-reactive protein/albumin ratio and endoscopic and mucosal activity in patients with ulcerative colitis. Material and Methods: In the study, 74 patients over the age of 18, who applied to the Gastroenterology and Inflammatory Bowel Diseases polyclinics of Inonu University Faculty of Medicine Gastroenterology Department between 2019-2021, who were diagnosed with ulcerative colitis pathologically, and who had sufficient data in laboratory tests and patient files, were examined. In the study, demographic characteristics such as age and gender, Rachmilewitz endoscopic activity index, and histopathological activity were determined. In the laboratory results of the patients, CRP, albumin, hemoglobin, leukocytes, neutrophils, monocytes, lymphocytes, thrombocyte and sedimentation values were examined. Results and Conclusion: When the patients were evaluated in terms of histological activity, those with active colitis had CRP (p<0,001), CRP/albumin (p<0,001), leukocytes (p=0,004), neutrophils (p=0,003), monocytes (p=0,009), thrombocyte (p<0,001) and sedimentation (p=0.001) values were found to be significantly higher than those without histologically active colitis, while albumin (p<0,001) and hemoglobin (p=0,031) values were found to be significantly lower. Those with endoscopically active colitis (EAI≥4) CRP (p<0,001), CRP/albumin (p<0,001), leukocytes (p=0,001), neutrophils (p=0,001), monocytes (p=0,024), platelets (p=0,002) and sedimentation (p=0,001) values were found to be significantly higher than those in remission endoscopically (EAI<4), and albumin (p=0,001) values were found to be significantly lower. It was observed that there was a positive and significant correlation between endoscopic activity and histological activity and the CRP/albumin ratio. The cut-off point was found to be 0,08 according to the ROC analysis performed on the CRP/albumin value according to the presence of active colitis. The sensitivity at this cut-off point was 75%, and the specificity was 96,67%. The positive predictive value was 97,06%, and the negative predictive value was 72,46%. Keywords: Ulcerative colitis, CRP/Albumin ratio, endoscopic activity