Catalytic synthesis of vitamin K3 (2-methyl-1,4-naphthoquinone)

In catalytic oxidation reaction of ß-methyl naphthalene to vitamin K3, [Mn(acac)3], [Cr(acac)3], [Ni(NO3)2] salts and Ru(II), Pd(II), Co(II), Ni(II) and Cu(II) complexes of free [N,N-bis(diphenylphosphinomethyl)aminopropylltrietoxisilane] ligand and its silica supported form syhntesized according to the reference were used as catalysts.H2O2 as clean oxidant, glaciyal acetic acid and sulfuric acid as solvent, Glass reactor, having a cooling water system wrapping around it, were used in the experiments. Efficiency of the oxidation reaction were studied on changing reaction parameters that reaction time, catalyst and H2O2 amount.