The effects of volatile anesthesia (Sevoflurane, and Desflurane), tiva of application blood cell of cytology and oxidant / antioxidant the system

In this study we aimed to investigate the effects of routinely used volatile anesthetics(desflurane, sevoflurane) and propofol for total intravenous anesthesia on blood cellcytology and oxidant / antioxidant system.Forty-five patients, ASA physical status I-II, ranging in age from 18 to 50 years, andscheduled to have general anesthesia for their surgical procedures (not major surgicaloperations) with approximate operation duration of 1-3 hours, were selected for thisstudy. The patients were divided into three groups. Venous blood was obtainedbefore induction and after surgery and total oxidant and antioxidant status,glutathione peroxidase, and blood cell counts were evaluated. Preoperative andpostoperative peripheral blood smear was examined in all cases. Histologicalpreparations were stained by Giemsa method and morphologies were evaluated bylight microscopy.As a result, in the postoperative period, the total oxidant capacity of desflurane groupand total antioxidant capacity of sevoflurane and TIVA group, were found to besignificantly increased when compared with preoperative period. There was nosignificant difference between preoperative period and postoperative period inrespect to Glutathione peroxidase levels in all groups. In the postoperative period,leukocyte count was significantly increased while lymphocytes were significantlydecreased in comparison with preoperative period. In TIVA group, postoperativecounts of neutrophils, eosinophils and basophils were found to be significantlyincreased than those in preoperative period. The examination of peripheral bloodsmears under a light microscope in preoperative and postoperative period revealedno abnormal blood cell morphological structure.