Production of different non-woven fabrics containing aging retardant vitamin B9 and investigation of controlled release

In this thesis work, the aim was to produce a protective shield by encapsulating folic acid (FA) - vitamin B9, which can decompose under humidity, temperature and UV, and spraying it on nonwoven surfaces, as well as fabricating nanofibers with different compositions, and to investigate its use as a cosmetic skin mask by studying its release behaviour under these conditions. An electrospinning device was used to produce nanofibers containing folic acid by the Pro-1, Pro-2 and Pro-3 methods. In Pro-4 method, folic acid as an active ingredient was loaded onto prefabricated nonwoven surfaces (melt blown and spunbond) using electrospray. The active substance release behaviour of each nonwoven surface was determined by UV-Vis analysis in an in-vitro environment (two different pH environments prepared according to the method ISO 105-E04). The addition of folic acid was used to determine changes in the diameters of the nanofibers with SEM analysis, the presence of folic acid loading in the nanofiber structures with FTIR and NMR analysis and changes in molecular structure, the thermal behaviour of the active substances and polymeric materials with DSC analysis, and differences in thermal decomposition behaviour with TGA analysis. It was tested whether the nonwoven surfaces produced by biocompatibility analysis damage the cell. It was found that all nonwoven fabrics, except PVA-PVP without FA polymer, did not damage the cell. It was found that all nonwoven surfaces prepared have FA molecule in their structure, FA can not be detected in core/shell and Pro-1 method and this is due to the fact that the polymer shields FA. The effect of FA was observed in the thermal degradation behaviour of all nonwoven surfaces with FA. The effects of release were evaluated from two different points of view, one is sudden release and the other is controlled release. PVA-FA (acid sweat medium, 95% release rate) nanofiber structures fabricated by Pro-1 method showed the best performance in sudden release. In controlled release, the highest release was PVA-kit-FA (alkaline sweat medium) with a release rate of 95.2% and the longest sustained release was PCL FA (alkaline sweat medium) prepared by Pro-1 method with a release rate of 93.4%. It was observed that the lowest release occurred on the PVA Alg-Kit -sFA nanofiber surfaces prepared by Pro-2 and exhibited a sudden release character. Keywords: Nanofibers, electrospinning, folic acid, drug release, skin mask