New benzothiazole derivatives synthesis and pharmacological effects evaluation

Infectious diseases pose a growing threat to human health. The fact that microorganisms become resistant to antimicrobial drugs makes it difficult to treat microbial diseases effectively and leads to increased mortality rates if comorbid diseases are present. In recent years, the design and development of new therapeutic agents to treat microbial infections has been of great importance. Within the scope of this thesis, 4-[((5-chlorobenzothiazole/benzothiazole-2-il)thio)methyl]-N'-(alkyl/arilmethylene) benzohydrazide (3a-3j) derivatives were synthesized by combining the benzothiazole ring with the hydrazide/hydrazone group. The final compounds were illuminated by 1H-NMR, 13C-NMR, and mass spectroscopy. Antibacterial and antifungal activities of the compounds have been reported against gram-positive and gram-negative bacteria and fungi. When the minimum inhibitory concentration was evaluated, compound 3d had an MIC of 312.5 µg/mL against Aeromonas hydrophila among gram-negative bacteria (chloramphenicol MIC: 78.12 µg/mL) and 3a and 3c against Bacillus cereus among gram-positive bacteria (chloramphenicol MIC of 78.12 µg/mL). The compounds showed antibacterial effect with a MIC value of 312.5 µg/mL. Among filamentous molds, 3a and 3b (MIC 312.5 µg/mL) against Aspergillus niger (ketoconazole MIC: 78.12 µg/mL); 3d, 3e, 3g and 3i (MIC 312.5 µg/mL) against Aspergillus flavus and compounds 3d and 3i (MIC 312.5 µg/mL against Aspergillus parasiticus were found to be the compounds showing the highest antifungal activity.