Synthesis and characterization of new mono- and dihydroxamic acids and metal complexes

In this work, paracetamolbütanohydroxamic acid and sodium benzoylureabütanohydroxamate and their transition metal complexes were synthesized starting from the drug active ingredients. Spectroscopic, magnetic and thermal properties and some biological activities of the compounds were investigated. Synthesis section consists of two stages. In the first stage, synthesized acetoethyl esters of paracetamol and benzoyleneurea were converted to paracetamolbutanohydroxamic acid and sodium benzoylureabutanohydroxamate. In the second stage, metal complexes were prepared by reaction of ligands with metal salts in the aqueous media. The structures of ligands and complexes were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and Mass spectroscopy techniques. Magnetic susceptibilities of complexes were measured and spin-only magnetic moments were calculated. As a result of the studies, metal/ligand ratio were found 1:1 for Cd and Ni, 1:2 Cu ve Zn complexes of the paracetamolbütanohydroxamate complexes and 1:1 for Cd and Ni, 1:2 Cu ve Zn complexes of the benzoyllureaohydroxamate and all complexes contain different number of water molecules.