Yeni sülfonamit sübstitüe şif baz türevlerinin sentezi ve biyolojik değerlendirilmesi

ABSTRACT BELHULA, M. Synthesis and Biological Evaluation of Some Sulfonamide Substituted Schiff Base Derivatives. Yeditepe University, Institute of Health Sciences, Department of Pharmaceutical Chemistry, MSc Thesis, Istanbul, 2022. Cancer is a dangerous life-threatening disease that involves uncontrolled cell development and their rapid spread, with the potential to harm normal tissues. Today, search and development of new anticancer agents are required. Recent studies demonstrated the promising antiproliferative activity of sulfonamide substituted Schiff base structures. In this work, we aimed to develop some novel sulfonamide substituted schiff base derivatives to evaluate their cytotoxic activity on a series of ovarian cancer cells. The schiff bases were synthesized using o-phenylendiamine and salicylaldehyde The obtained Schiff bases were further treated with different sulfonyl chloride derivatives to form the targeted sulfonamide substituted compounds. Structure elucidation of the synthesized compounds was performed by FT-IR, 1H NMR, 13C NMR and LC-MS spectral analyses. Compounds were then evaluated for their biological activity using the NCI-Sulforhodamine B assay on OVCAR-3, OVSAHO and KUROMOCHI and CAOV-3 ovarian cancer lines. Most of the compound showed moderate to no cytotoxicity against these ovarian cancer cell lines. Yet IC50 values of 16.99, 3.31, 17.55 and 6.53µM for compound 5 and 71.52, 9.87, 42.17,and 16.95µM for compound 7 respectively. 5 7