nvestigation of the relationship of dietary inflammatory index with disease activity, depressive mood and some biochemical blood parameters in adult inflammatory bowel disease patients

In this study, it was aimed to determine the relationship between dietary inflammatory index (DII) and disease activity, depressive mood and some biochemical blood parameters in adult inflammatory bowel disease patients. The study included 94 individuals, 31 of whom were diagnosed with crohn's disease and 63 of whom were ulcerative colitis patients, who applied to the Gazi University Hospital Gastroenterology Polyclinic between June and October 2021. The participants' socio-demographic characteristics, general health information, disease activity indices and some biochemical blood parameters were recorded in the questionnaire. The dietary inflammatory index of the individuals was calculated by taking three-day food consumption records from the individuals. The dietary inflammatory index scores of the individuals were evaluated by dividing them into four quartiles, and as the numerical value of the quartiles increased, the inflammatory load of the diet also increased. In addition, Beck Depression Inventory was used to determine the depressive mood of individuals. The Crohn's Disease Activity Index in patients with crohn and the Truelove-witts Clinical Activity Index in ulcerative colitis patients were used to determine disease activity. The mean age of the individuals included in the study was 42.0±11.1 years for patients with crohn's (CH) and 42.5±15.3 years for patients with ulcerative colitis (UC). The mean dietary inflammatory index scores of the individuals were determined as -3.15 ± 0.9. Presence of depression was found to be statistically significant in crohn's and ulcerative colitis patients with more disease activity (p<0.05). It was stated that both crohn's patients and ulcerative colitis patients had a statistically significant higher depression score as the disease activity increased (p<0.05). There was no significant difference between Crohn's patients and ulcerative colitis patients according to dietary inflammatory index quartiles (p>0.05). There was no significant difference between the disease activities according to the dietary inflammatory index quartiles of Crohn's patients (p>0.05). There was no significant difference between disease activities according to dietary inflammatory index quartiles of ulcerative colitis patients (p>0.05). When the blood biochemical parameters of the individuals included in the study were examined according to the dietary inflammatory index quartiles, a significant difference was observed only between CRP and serum iron levels (p<0.05). There was also a significant difference between depression status according to diet inflammatory index quartiles (p<0.05). Individuals with high dietary inflammatory index had significantly lower intakes of energy, carbohydrate, protein, fat, saturated fat, polyunsaturated fat, omega-3, omega-6, cholesterol and fiber in daily diet compared to others (p<0.05). Individuals with a low dietary inflammatory index have a significantly higher daily intake of vitamin A, vitamin D, thiamine, riboflavin, niacin, vitamin B6, folic acid, vitamin B12, vitamin C, iron, magnesium, zinc and selenium compared to others (p<0.05). In conclusion, it has been shown that the inflammatory index of diet affects mood and some biochemical parameters in patients with inflammatory bowel disease. According to the results of this study, it is thought that many chronic diseases caused by inflammation can be prevented or delayed with a healthy and less inflammatory diet in individuals with inflammatory bowel disease.