Investigation of electrochemical behaviour of zopiclone by voltametric methods and quantitative determination in tablets

ABSTRACTElectrochemical oxidation behaviour of active compounds namely zopiclonewas investigated by voltammetric methods using glassy carbon electrode. Indifferent supporting electrolyte, oxidation was studied by voltammetric methods toinvestigate the optimum conditions. pH=7,08 BRT solution in which sharp peak andmaxium current was observed, at glassy carbon electrode for zopiclone, wasselected as supporting electrolyte. The effects of pH on the peak current and peakpotential for material was investigated by adsorptive stripping differential pulsevoltammetry (AdSDPV) and adsorptive stripping osteryoung square voltammetry(AdSOSW), the effect of scan rate on the peak current was investigated by cyclicvoltammetry (CV) techniques. The linearity range ( for AdSDPV 6x10-7-2x10-5mol L-1; for AdSOSW 8x10-7-2x10-5 mol L-1) was determined from peak current-concentration curves which obtained AdSDPV and AdSOSW techniques. Limit ofdetection (LOD) and limit of quantitation (LOQ) calculated using these curves.In order to check accucarcy and precision of applied voltammetric method,recovery experiments of zopiclone was carried out from the drug tablets.Furthermore, the amount of zopiclone was determined in commercial drug tablets.Keywords: Zopiclone, Adsorptive stripping differantial pulse voltametry,Adsorptive stripping osteryoung square voltametry, Glassy carbon electrode,Commercial drug tablets.VII