Sağlık Eğitimi Anabilim Dalı

Türk popülasyonunda prostat kanseri hastalarında DNA hasarı bağlayan protein 2 (DDB2) gen polimorizminin araştırılması

AIM: To investigate in the Turkish population the gene variation of the DDB2 gene rs830083 polymorphism and prostate cancer (PC). MATERIALS and METHODS: The SNPs of the DDB2 gene rs830083 will be genotyped using TaqmanR SNP Genotyping Assays and BioScience (ABI), real-time 7500 PCR system. The statistical analysis was carried out using SPSS version 26.0. This research project will be a case-control retrospective study comprising 93 patients with prostate cancer and a control group which consisted of 91 healthy individuals. RESULTS: In this study, DDB2 gene (rs830083) polymorphism was analyzed in individuals with Prostate Cancer and control group. Although, there were no significant difference regarding genotype analysis (p=0.216), G allele frequency was significantly higher in the control group 46.2% (p = 0.037). In genotype distribution, of GC was significantly higher in the control group and CC genotype was significantly higher in the patient group, frequency was 26.9% and C 68.8% (p value = 0.048 and 0.037). CONCLUSION: It is the first study investigating the relation between DDB2 gene variations (rs830083) with PC in Turkish populations. Our findings displayed that carrying G allele could be a risk reducing factor for PC susceptibility. Thus, new studies with larger populations should be conducted with the DDB2 polymorphism to show the effect of DDB2 on PC susceptibility. Keywords: DNA Damage Binding Protein, Prostate cancer, (DDB2) gene (rs830083) polymorphism.