Assessment of the relationship between specific hematological parameters versus mortality and morbidity in patients with gastrointestinal bleeding

Assessment of the relationship between specific hematological parameters versus mortality and morbidity in patients with gastrointestinal bleeding Aim: The purpose of our study was to investigate whether demographic, clinical and laboratory parameters are correlated with mortality and morbidity in patients diagnosed with (gastrointestinal) GI bleeding in the emergency department. Materials and Methods: Our study was performed retrospectively and it included 113 patients who were admitted to the emergency department with GI bleeding between 01.06.2018-01.06.2019. Patients' gender, age, complaints, comorbidities and drug use, bleeding area, laboratory parameters, endoscopy findings, hospitalization units and mortality status were investigated. Kolmogorov-Smirnov, Mann Whitney-U, Chi-square, Fisher Exact and logistic regression analysis were used for the statistical data analysis. Results: The median age of the study subjects was 67 years, with a gender representation of 61.9% male patients. Comorbidities were detected in 67.3% of the patients. The frequency of ulcerative colitis, hemorrhoids and other comorbidities was high in patients with lower GI bleeding (p<0.05). In cases with upper GI bleeding, the frequency of hematemesis and melaena is significantly high, while in the cases presenting lower GI bleeding, the frequency of hematochezia is significantly high (p<0.05). İn our study the median value registered for the blood tests as it follows: Hb 9 gr/dl, Hct %27,5, MPV 10,4 μl, trombosit 225 x103/mm3.There was no relationship between the localization of the GI bleeding and mortality and Hb, Hct, MPV or platelet values (p> 0.05). Median value found for creatinine, BUN and BUN/creatinine ratio is 0,8 mg/dl, 24 mg/dl, and respectively 26. Also, there was no relationship between Açıklamalı [i1]: Açıklamalı [i2]: The meaning of the word level in this context is similar with the word degree, as in the quantity of the bleeding which is a hard paramethers to quantify and probably it has not being done in your study. I think you wanted to say the origin of the bleeding, upper or lower GI tract, right? If I am wrong, keep the word level. GI bleeding localization and creatinine level (p> 0.05). BUN level and BUN / creatinine ratio were significantly higher in patients with upper gastrointestinal bleeding (p <0.05). Regarding hospitalization, 47.8% of the cases were followed-up in a regular hospital ward and 52.2% in intensive care unit. It was determined that the mortality rate was 4.4% and no factor was found to affect mortality alone (p> 0.05). Conclusion: We can state that although many factors in GI bleeding cases had an effect in the patient clinical aspects, it has not influenced the mortality. This might be related to the low number of patients and mortality rates registered in our study to the number of patients with mortality. Therefore, larger case series are needed. Keywords: Gastrointestinal bleeding, emergency department, hematological parameters, mortality