Patients presenting to the emergency department with ST-elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI) were evaluated for the impact of mean platelet volume (MPV), red cell distribution width (RDW), and st elevation in the aVR lead on short-term mortality

Examining new biomarkers for Acute Coronary Syndrome (ACS) is an important research area, as it can lead to earlier diagnosis, more effective treatment plans, and improved prognosis. Nowadays, diagnosis of ACS quickly and accurately is of great importance in terms of starting treatment more effectively and improving the prognosis of patients. It investigated the effects of mean platelet volume (MPV), erythrocyte distribution width (RDW), and ST elevation in the aVR lead on short-term in-hospital (30-day) mortality. Between January 1, 2020 and January 1, 2023, patients who presented to the emergency department with cardiac complaints and had ST segment elevation on the admission electrocardiogram (ECG) and underwent percutaneous coronary intervention (PCI) were included. In our study, demographic information, electrocardiogram, hemogram and 30-day mortality information of the patients were used as data. Data were obtained through the hospital information management system, death notification system or telephone contact. The average age of the patients was 61.34. Of the STEMI patients, 268 (81.5%) were male and 61 (18.5%) were female. Of the patients who had STEMI, 148 (45%) had inferior MI, 159 (48.3%) had anterior MI, and 22 (6.7%) had other MI. Coronary artery bypass graft (CABG) was applied to 34 patients (10.3%). In the laboratory values of the patients; leukocyte (WBC) 12.16 ×109/L, hemoglobin (HGB) 14.14 g/dL, MPV 9.55 fl, neutrophil/lymphocyte ratio (NLR) 5.20, CRP 18.92 mg/L, CK- MB was 18.92 ng/ml, troponin was 408.89 ng/ml, INR was 1.07 and RDW was 13.87%. MI variety; It was not significant according to gender, hypertension (HT), diabetes (DM), coronary artery disease (CAD), mortality and age. As a result of comparing ST elevation and laboratory values (WBC, HGB, RDW, MPV, NLR, CRP, CK-MB, INR) in aVR, no statistically significant difference was observed between them. Troponin was lower in patients with ST elevation in aVR at 117.38 ng/ml and was statistically significant (p<0.050). In comparing mortality and clinical features, no statistically significant difference was observed between gender, HT, CAD, other diseases, and mortality. The presence of DM was equal in patients with mortality, but it was less in patients without mortality (28.8%), showing a statistically significant difference (p<0.050). There was no significant difference between the mortality rate and WBC, HGB, RDW, MPV, NLR, and CK-MB values. A positive relationship was found between age and the presence of HT (r=0.151/p=0.006), DM (r=0.136/p=0.014), other chronic diseases (r=0.170/p=0.002), and mortality (r=0.192/p=0.000), indicating a very low directional correlation. As age increases, hypertension, DM, other chronic diseases, and mortality also increase. In conclusion: When laboratory findings were examined according to the type of MI in patients who presented to the emergency department with a diagnosis of STEMI, it was seen that similar results were obtained. Additionally, Troponin was significantly lower in patients with aVR elevation. Mortality and HGB, RDW, NLR, CRP, troponin, and INR were significant. Age and mortality were equally significant. We think that the wide range in the laboratory parameters of our patients and the size of the standard deviation affect the statistical significance. We think that the study should be repeated with more parameters and number of patients in predicting mortality in STEMI. Key Words: Emergency department, Acute Coronary Syndrome, STEMI