Analjezik etkili bazı polifenollerin dorsal kök gangliyon nöronları üzerindeki elektrofizyolojik etkileri

Pain is one of the conditions that limit the productivity and decrease the quality of life of affected patients. Despite the presence of plenty of effective analgesic, there is a great concern regarding their safety and adverse effects. Quercetin and some other polyphenols play an important role as anti-inflammatory, analgesic, and antioxidant agents. This study was performed on acutely dissociated dorsal root ganglion cells to investigate the effect of three agents (rosmarinic acid, quercetin, and gallic acid) in terms of parameters about cell excitability. The whole cell configuration of the patch clamp technique has been used to evaluate total outward currents and action potential parameters. Control groups were the same test cell groups taken from the same animal. Electrophysiological recordings from dorsal root ganglion cells showed that rosmarinic acid, quercetin, and gallic acid significantly reduce maximal K+ conductance over the membrane potential range tested and shift the peak current and conductance towards more positive membrane potentials. Action potential parameters have been changed after the administration of the chemicals in favor of an inhibition, like the effect observed consequently for K+ currents. Results obtained indicates that the inhibition on K+ currents the substances induce is not concentration dependent. In conclusion, this study clearly presented that the phytochemicals used have the potential to be promising drugs to relieve pain and further research based on this study will provide an efficient approach.