Electrochemical preperties of aripiprazole and its anodic adsorptive sitripping determination in pharmaceutical and biological fluids

In this study, electrochemical behavior of aripiprazole (ARP), was investigated on aluminum oxide nanoparticles modified carbon paste electrode (Al2O3 NP-CPE) in Britton-Robinson buffer (BR) by cyclic voltammetry (CV) and square wave voltammetry (SWV) and adsorption properties of ARP were investigated. Furthermore, square wave anodic adsorptive stripping voltammetric (SWAAdSV) method was developed to its direct determination in human serum and tablette samples. The peak current of the oxydation wave linearly changed with the concentration of ARP in the concentration range between 3.0×10–8 mol L–1 and 8.0×10–6 mol L–1 in two different regions where optimum pre concentration potential and optimum pre concentration time were applied as –0.00 V and 150 s, respectively. Limit of detectionand limit of quantitation were calculated from analytical parameters of calibration studies by using leasts quared method. Limit of detection and limit of quantitation values calculeted as first linear range 5.70×10-9 mol L-1, 1.90×10-9 mol L-1 and 2.82×10-7 mol L-1, 9.41 ×10-7 mol L-1 respectively. Validation of method was also performed. Results of applications of developed method to human serum and tablette samples were found to have high accuracy and precision, reproducible and high confidence. These results were also compared with those of standart methods proposed for determination of ARP and results were found to be in significant at 95% confidence level.